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KMID : 1134820200490121400
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 12 p.1400 ~ p.1406
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Filtered Coffee Lowers Intestinal Cholesterol and Fat Absorption in Rats
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Kim Ju-Yeon
Ju So-Yoon
Noh Sang-Kyu
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Abstract
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Coffee is a complex mixture of biologically active components such as chlorogenic acids and caffeine, which may affect human health. However, there has been a long-standing controversy regarding its impact on lipid metabolism. This study was conducted to determine the role of filtered coffee in lowering intestinal absorption of cholesterol and fat in rats. Rats with lymph duct cannulae were infused with a lipid emulsion at 3.0 mL/h for 8 h via an intraduodenal catheter. The lipid emulsion contained a mixture of 33.3 kBq 14C-cholesterol, 20.7 μmol of cholesterol, 396.0 μmol of Na-taurocholate, 3.1 μmol of α-tocopherol, 452.0 μmol of triolein, and 75.4 μmol of retinol. The rats were divided into two groups, the control and the coffee group. The control group was administered lipid emulsion without filtered coffee and the coffee group was administered lipid emulsion with filtered coffee in phosphate buffered saline (pH 6.4). Lymph was collected hourly for 8 h. Filtered coffee significantly lowered the intestinal absorption of 14C-cholesterol (38.16±3.18% dose/8 h in the control group vs. 25.01±5.75% dose/8 h in the coffee group). Also, filtered coffee markedly lowered oleic acid absorption. The findings provide direct evidence that filtered coffee has a profound inhibitory effect on the intestinal absorption of cholesterol and fat.
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KEYWORD
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filtered coffee, cholesterol, fat, absorption, rat
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